Mechanisms for redox-regulation of protein kinase C
نویسندگان
چکیده
منابع مشابه
Mechanisms for redox-regulation of protein kinase C
Protein kinase C (PKC) is comprised of a family of signal-regulated enzymes that play pleiotropic roles in the control of many physiological and pathological responses. PKC isoforms are traditionally viewed as allosterically activated enzymes that are recruited to membranes by growth factor receptor-generated lipid cofactors. An inherent assumption of this conventional model of PKC isoform acti...
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Oxidants were once primarily considered in biology and medicine in terms of the injury they might cause. However, oxidants are now known to play crucial roles in homeostatic control of cells and tissues during health. Oxidative modification of proteins with a coupled alteration in function allows cells to sense and transduce these 'oxidant signals' into a biological response. We looked for prot...
متن کاملRegulation of protein kinase C.
Protein kinase C has been in the spotlight since the discovery two decades ago that it is activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring stage presence, the regulation and specific roles of its isozymes in defined cellular processes are still under intense investigation. Elucidation of the structures of protein kinase C's regulatory modules, the disc...
متن کاملA direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.
In this study, we have used the PC12 cell model to elucidate the mechanisms by which sublethal doses of oxidants induce neuritogenesis. The xanthine/xanthine oxidase (X/XO) system was used for the steady state generation of superoxide, and CoCl(2) was used as a representative transition metal redox catalyst. Upon treatment of purified protein kinase C (PKC) with these oxidants, there was an inc...
متن کاملRedox Regulation of the AMP-Activated Protein Kinase
UNLABELLED Redox state is a critical determinant of cell function, and any major imbalances can cause severe damage or death. OBJECTIVES The aim of this study is to determine if AMP-activated protein kinase (AMPK), a cellular energy sensor, is activated by oxidants generated by Berberine in endothelial cells (EC). METHODS Bovine aortic endothelial cells (BAEC) were exposed to Berberine. AMP...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2015
ISSN: 1663-9812
DOI: 10.3389/fphar.2015.00128